Discovery of biomarkers in breath: Development and optimisation of a TD–GCxGC–TOF MS analytical platform

This study describes the development of an analytical platform based upon TD–GCxGC–TOF MS and shows its application to the collection and analysis of breath samples. The enhanced separation achieved ensures confident identification of biomarkers. Key advantages of the system are the superior repeatability of flow modulated GCxGC and excellent linearity.

Other advantages include thermal desorption – thanks to trap focusing – ensuring the introduction of VOCs in a narrow band, for optimal chromatography and high sensitivity, and the INSIGHT GCxGC flow modulator, which provides efficient modulation of volatiles using cryogen-free flow modulation for enhanced separation of complex breath profiles and robust biomarker discovery.

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