Time-of-flight Mass Spectrometry

Time-of-flight Mass Spectrometry
BenchTOF2
BenchTOF2
BenchTOF2
BenchTOF2
BenchTOF2 with Sample Preparation Robot (SPR)
BenchTOF2 with Sample Preparation Robot (SPR)
BenchTOF2 with Centri extraction and enrichment platform
BenchTOF2 with Centri extraction and enrichment platform

BenchTOF2 time-of-flight mass spectrometers

BenchTOF2™ mass spectrometers are the next generation of the successful BenchTOF series of time-of-flight (TOF) mass spectrometers, allowing labs to adapt to increased workloads and new challenges, while improving data confidence and reducing costs.

Like all TOF instruments, BenchTOF2 simultaneously analyses all ions, maximising sensitivity and providing full-range spectra for both target compounds and unknowns in a single run. Conventional quadrupoles, in contrast, work by mass filtering, which wastes ions and results in lower sensitivity (and SIM mode, while enhancing sensitivity, is not able to analyse unknowns).

At SepSolve, we incorporate the power of BenchTOF2 into connected workflows tailored for your application. This allows you to transition easily between ‘discovery’ and routine applications, and maximise the amount of information extracted from every sample.

 

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WHY USE BENCHTOF2?

  • Identify analytes confidently through an unbeatable combination of SIM-level sensitivity, high-quality spectra, excellent selectivity and smart software tools.

  • Improve detection limits with full spectral information, and so detect a wide range of trace-level species in a single analysis, with the option of retrospective searching for new compounds of interest.

  • Extend dynamic range across five orders of magnitude: accurately quantify high-concentration compounds while maintaining low detection limits, and so remove the need for dilutions or repeat analyses.
     
  • Carry out fast GC and GC×GC separations thanks to BenchTOF2’s fast acquisition speeds.
     
  • Simultaneously acquire hard and soft EI spectra using patented Tandem Ionisation® technology, and so confidently identify challenging compounds (e.g. isomers) in streamlined workflows.

  • Increase productivity through use of H2 carrier gas, for lower cost of ownership, fast return on investment, faster chromatographic separations, and easier implementation for new labs.

  • Minimise training: BenchTOF2 combines instrument control, method development, data analysis and chemometrics in a single user interface, and is easily learnt by non-MS experts.



Applications

Technical note: Improving discovery workflows using Tandem Ionisation® data
This technical note demonstrates how Tandem Ionisation data can be used to improve discovery workflows by reducing the frequency of false positives and describes how this is achieved using an untargeted, tile-based approach used in ChromCompare+ software to find the significant class-based differences between GC and GC×GC chromatograms.
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Technical note: Tandem Ionisation – Revolutionary soft ionisation to enhance CONFIDENCE IN IDENTIFICATION
This technical note describes the use of Tandem Ionisation® for BenchTOF2™ mass spectrometers to acquire both hard (70 eV) and soft (10–20 eV) electron ionisation (EI) in a single analysis.
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Why Choose a Time-Of-Flight Mass Spectrometer
In this technical note, we explore such advantages of TOF MS, specifically SepSolve’s BenchTOF2™ instruments, with examples for both research and routine applications.
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Analysis of complex phthalate mixtures by GC–TOF MS with Select-eV soft ionisation
This study shows how the acquisition of ‘soft’ electron ionisation spectra offers significant advantages for the GC–MS analysis of phthalates.
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Comprehensive screening of volatile emissions from plastics
This study demonstrates the use of a discovery platform combining thermal desorption with GC×GC–TOF MS for comprehensive screening of emissions from plastics.
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New car smell: Improved identification of odours in vehicle interior air
This study demonstrates the discovery of odour compounds using thermal desorption with GC×GC–TOF MS. This provides target and non-target screening of car trim components on a single platform, for advanced analysis of vehicle interior air quality (VIAQ).
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Improved characterisation of malodours in recycled plastics using TD–GC×GC with BenchTOF2 MS
Thermal desorption (TD) with GC×GC–TOF MS can be used for comprehensive characterisation of volatiles from recycled plastics, and the method is simple to translate to routine screening in QC labs.
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Improved characterisation of materials using pyrolysis with GC×GC–TOF MS
Pyrolysis coupled with two-dimensional gas chromatography and time-of-flight mass spectrometry (Py–GC×GC–TOF MS) can be used for quality control of consumer products, including tyres, plastics and paper.
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Discovery of biomarkers in breath: Enhancing separation and identification using GC×GC–TOF MS
This study describes the comprehensive, high-sensitivity screening of disease biomarkers, through use of sampling onto TD tubes, automated preconcentration, and GC×GC–TOF MS, with confident identification aided by Tandem Ionisation.
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Discovery of biomarkers in breath: Efficient screening with TD–GC–TOF MS
This study describes an analytical system for the rapid identification of potential disease biomarkers in breath, through the use of sampling onto TD tubes, followed by automated preconcentration and GC–TOF MS.
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Discovery of biomarkers in breath: Development and optimisation of a TD–GC×GC–TOF MS analytical platform
This study describes the development of an analytical platform based upon TD–GC×GC–TOF MS and shows its application to the collection and analysis of breath samples. The enhanced separation achieved ensures confident identification of biomarkers.
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Uncovering hidden compositional changes in breath profiles using untargeted chemometric workflows
This study describes the use of thermal desorption (TD) and GC×GC–TOF MS for exploratory profiling of biomarkers in breath, coupled with innovative data mining tools to uncover hidden compositional changes using automated untargeted workflows.
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Determining petrochemical composition by GC×GC–TOF MS/FID: Reliable, automated group-type analysis
This article illustrates how ChromSpace software, in conjunction with dual TOF MS/FID detection and Tandem Ionisation, can streamline the process of achieving robust and reliable analyte speciation and quantitation of complex petrochemicals in an acceptable time frame.
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Determining petrochemical composition by GC×GC–TOF MS/FID: The benefits of flow modulation and Tandem Ionisation
This study demonstrates the performance of a flow-modulated GC×GC system for the analysis of complex petrochemicals, with the INSIGHT modulator providing efficient and repeatable modulation without the need for expensive liquid cryogen.
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Fast and efficient group-type (PiPNA) classification of jet fuels
This study demonstrates the performance of flow-modulated GC×GC for robust group-type characterisation of jet fuels, with quantitative analysis by flame ionisation detection and confident identification of trace-level contaminants by mass spectrometry.
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Uncovering trace additives in gasoline
This study demonstrates the use of GC×GC coupled with BenchTOF2 and Tandem Ionisation to identify trace additives in gasoline, with time-saving workflows in ChromCompare+ software utilising all of the tandem data in a single workflow to automatically uncover differences between gasoline blends.
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Improving confidence in the quantitative analysis of cannabis terpenes using flow-modulated GC×GC–FID
This study demonstrates the use of flow-modulated GC×GC–FID to streamline profiling of cannabis terpenes and terpenoids. A key feature is the enhanced separation provided by GC×GC, which improves confidence in compound identity and data quality.
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Enhanced characterisation of cannabis extracts using flow-modulated GC×GC–TOF MS/FID with Tandem Ionisation
This study demonstrates the use of flow-modulated GC×GC to detect cannabinoids and terpenoids in complex cannabis extracts, with simultaneous detection by FID for robust quantitation and TOF MS for confident identification (aided by Tandem Ionisation).
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Tobacco Smoke Analysis with Tandem Ionisation
This study demonstrates the enhanced separation and unparalleled sensitivity that can be achieved in the characterisation of cigarette smoke, using thermal desorption (TD) and flow-modulated GC×GC with TOF MS, aided by Tandem Ionisation for simultaneous acquisition of NIST-quality 70 eV spectra and complementary soft EI spectra.
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Quantitation of residual solvents and terpenes in cannabis products – a combined approach
This study describes a combined approach for fast, targeted screening of residual solvents and key terpenes, as well as a discovery route for enhanced separation of terpenes and terpenoids and greater insight into cannabis aroma.
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Comprehensive aroma profiling of cannabis using a discovery workflow
This study describes the use of GC×GC–TOF MS for exploratory profiling of terpenes and other aroma-active compounds in cannabis flowers.
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Confident profiling of controlled substances using GC–TOF MS
This study describes the use of GC–TOF MS for comprehensive profiling of seized drug samples, for confident identification of controlled substances, as well as adulterants and cutting agents.
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Tackling the extended list of fragrance allergens by flow-modulated GC×GC–TOF MS
This study investigates the use of flow-modulated GC×GC to analyse an 84-component allergen calibration standard, with simultaneous detection by TOF MS for confident identification and FID for robust quantitation. The validity of the method is then demonstrated with the examples of essential oils and a fragrance mix.
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Enhanced separation of hop oils by flow-modulated GC×GC–TOF MS
This study demonstrates the high performance of a flow-modulated GC×GC–MS system for the evaluation of complex hop oils, which allows effective modulation of even the most volatile components without the need for expensive liquid cryogen. Analyte speciation is also aided by Tandem Ionisation for simultaneous acquisition of hard and soft EI data.
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Comparison of the aroma profiles of hops using dynamic headspace sampling with TD–GC–TOF MS
This study demonstrates the high performance of a dynamic headspace sampler with TD–GC–TOF MS analysis for investigating the complex aroma profiles from three varieties of hops.
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Detailed characterisation of essential oils by flow-modulated GC×GC and Tandem Ionisation mass spectrometry
In this study, flow-modulated GC×GC–TOF MS with Tandem Ionisation is used to characterise essential oils in fine detail, allowing the in-depth comparison of their compositions that aids rigorous quality control, particularly in the fragrance industry.
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Evaluating the authenticity of branded perfumes
This study demonstrates how the comprehensive data acquired using GC×GC–TOF MS with Tandem Ionisation® can be processed in a single, automated workflow to uncover the subtle differences between brand and imitation fragrances.
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Fully automated on-line headspace monitoring of VOCs
This study demonstrates a fully automated GC analysis of volatile organic compounds (VOCs) in the headspace of waste effluent using a flow-through cell with a sample preparation robot, and detection by FID and/or TOF MS.
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Fast analysis of semi-volatile organic compounds using PTV-GC–TOF MS
This study demonstrates the improvements in efficiency and sensitivity that can be achieved by using programmed temperature vaporisation (PTV) with GC and time-of-flight mass spectrometry (TOF MS) for the analysis of semi-volatile organic compounds relevant to environmental monitoring.
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Routine monitoring of airborne VOCs using TD–GC×GC–TOF MS/FID
This study demonstrates the suitability of a TD–GC×GC system with dual TOF MS/FID detection for the routine, automated analysis of VOCs in complex humid air samples.
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Rapid quantitation of azo dyes in water and textiles by GC–TOF MS
This study describes the use of fast GC–TOF MS for high-throughput analysis of azo dye aromatic amines in textiles and water.
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Reliable speciation of fatty acid methyl esters (FAMEs)
This study demonstrates the use of flow-modulated GC×GC to analyse a FAME standard and FAMEs from a butter extract, with simultaneous detection by TOF MS and FID for improved speciation. Tandem Ionisation is used to add an additional level of confidence for compounds exhibiting weak molecular ions and/or similar spectra at 70 eV.
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Aroma profiling of pet food using high-capacity sorptive extraction and TD–GC×GC–TOF MS
This study demonstrates the use of high-capacity sorptive extraction, with analysis by TD–GC×GC–TOF MS, for the aroma profiling of meat-based cat food, including the reliable detection of trace off-odour components.
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Flavour profiling of milk using high‑capacity sorptive extraction and TD–GC×GC–TOF MS/FID
This study demonstrates the high performance of PDMS sorptive extraction probes, coupled with thermal desorption pre‑concentration and flow-modulated GC×GC–TOF MS/FID analysis, for the separation and identification of flavour compounds in milk.
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Rapid aroma-profiling of cookies by dynamic headspace sampling and TD–GC–TOF MS
This study shows the value of dynamic headspace sampling and thermal desorption–GC–TOF MS analysis to rapidly profile volatile compounds released from flavoured cookies, and avoid the problems typically encountered when using solvent-extraction methods.
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Comparison of aroma compounds in whisky by SPME–GC×GC–TOF MS/FID
This study demonstrates the high performance of a flow-modulated GC×GC–TOF MS system, coupled with sample preparation by solid-phase micro-extraction (SPME), for the separation and identification of trace volatiles in three brands of whisky.
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Aroma profiling of hops and beer using high-capacity sorptive extraction with GC×GC–FID/TOF MS/SCD
This study demonstrates the use of a multi-hyphenated analytical system to provide flexible yet comprehensive aroma profiling of hops and beer, as well as detection of trace odour taints, on a single, fully‑automated platform.
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Automated aroma profiling of wine using sorptive extraction with GC×GC–TOF MS/SCD
This study demonstrates the use of headspace sorptive extraction coupled with GC×GC–TOF MS/SCD to provide comprehensive information on wine aroma and odour taints on a single, fully-automated, cryogen-free platform.
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Reverse engineering the aroma of plant-based meat substitutes
This study describes the use of headspace sorptive extraction with GC×GC–TOF MS to compare the volatile profiles of ground meat and plant-based substitutes.
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Investigating the quality of Darjeeling teas using comprehensive VOC fingerprints
This study demonstrates the use of immersive sorptive extraction and GC×GC–TOF MS to determine the characteristic flavour compounds in Darjeeling teas. Comparative analysis of different tea types and grades will be shown using streamlined workflows to improve quality assessment.
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Comparison of liquid smoke flavourings using GC×GC with BenchTOF2 and Tandem Ionisation
GC×GC coupled with high-performance BenchTOF2™ mass spectrometry and powerful software tools can provide comprehensive non-target screening of liquid smoke composition, to improve quality control procedures and to accelerate the development of new flavourings.
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Monitoring disinfection by-products in water using thin-film SPME coupled with GC×GC and BenchTOF MS
Thin-film solid-phase microextraction (TF-SPME) with comprehensive two-dimensional gas chromatography and BenchTOF™ time-of-flight mass spectrometry (GC×GC–TOF MS) provides efficient non-target screening of organic pollutants in water.
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